免疫化学分野

大阪大学 免疫学フロンティア研究センター 免疫化学研究室 / 微生物病研究所 免疫化学分野

学 歴
 1990.3   北海道大学 医学部 卒業
 1994.3   北海道大学 大学院医学博士課程 修了
職 歴
 1994.4   千葉大学 医学部 高次機能制御研究センター 遺伝子情報分野 助手
 2000.8   カリフォルニア大学サンフランシスコ校 研究員
 2002.8   千葉大学 大学院医学研究院 遺伝子制御学 助教授
 2004.2   大阪大学 微生物病研究所 免疫化学分野 助教授
 2006.6-現在 大阪大学 微生物病研究所 免疫化学分野 教授
 2007.10-現在 大阪大学 免疫学フロンティア研究センター 免疫化学研究室 教授
研究内容
 免疫システムと病原体との相互作用の解明/MHCによる自己免疫疾患の発症機序
業 績

代表論文

  • Jin, H., Arase, N., Hirayasu, K., Kohyama, M., Suenaga, T., Saito, F., Tanimura, K., Matsuoka, S., Ebina, K., Shi, K., Toyama-Sorimachi, N., Yasuda, S., Horita, T., Hiwa, R., Takasugi, K., Ohmura, K., Yoshikawa, H., Saito, T., Atsumi, T., Sasazuki, T., Katayama, I., L. Lanier, L., and Arase, H. Autoantibodies to IgG/HLA-DR complexes are associated with rheumatoid arthritis susceptibility. 2014. Proc. Natl. Acad. Sci. USA. 111: 3787-3792. [Link]
  • Wang, J., Shiratori, I., Uehori, J., Ikawa, M., Arase, H. 2013. Neutrophil infiltration during inflammation is regulated by PILRα via modulation of integrin activation. Nat. Immunol. 14:34-40. [Link]
  • Suenaga, T., Satoh, T., Somboonthum, P., Kawaguchi, Y., Mori, Y., and Arase, H. 2010. Myelin-associated glycoprotein mediates membrane fusion and entry of neurotropic herpesviruses. Proc. Natl. Acad. Sci. USA 107:866-871.[Link]
  • Satoh, T., Arii, J., Suenaga, T., Wang, J., Kogure, A., Uehori, J., Arase, N., Shiratori, I., Tanaka, S., Kawaguchi, Y., Spear, P.G., Lanier, L.L. and Arase, H. PILRα is a herpes simplex virus-1 entry co-receptor that associates with glycoprotein B. Cell 2008 132:935-944.
  • Wang, J., Shiratori, I., Satoh, T., Lanier, L.L., and Arase, H. An essential role of sialylated O-linked sugar chains in the recognition of mouse CD99 by paired immunoglobulin-like type 2 receptor (PILR). J. Immunol. 2008 180:1686-1693.
  • Adams, E. J., Juo, Z. S., Venook, R. T., Boulanger, M. J., Arase, H., Lanier, L. L., and Garcia, K. C. Structural elucidation of the m157 mouse cytomegalovirus ligand for Ly49 natural killer cell receptors. Proc. Natl. Acad. Sci. USA. 2007 104:10128-10133.
  • Shiratori, I., Yamaguchi, M., Suzukawa, M., Yamamoto, K., Lanier, L.L., Saito, T. and Arase, H. Downregulation of basophil function by human CD200 and human herpesvirus-8 CD200. J. Immunol. 2005 175:4441-4449.
  • Shiratori, I., Ogasawara, K., Saito, T., Lanier, L. L., and Arase, H. Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor. J. Exp. Med. 2004 199:525-533.
  • Ohtsuka, M., Arase, H., Takeuchi, A., Yamasaki, S., Shiina, R., Sakurai, D., Arase, N., Suenaga, T., Iwashima, M., Kitamura, T., Moriya, H., and Saito, T. NFAM1, a new ITAM+ cell surface molecule that regulates development and signaling of B lymphocytes. Proc. Natl. Acad. Sci. USA. 2004 101:8126-8131.(First two authors equally contributed)
  • Carlyle, J.R., Jamieson, A.M., Gasser, S., Clingan, C.S., Arase, H., and Raulet, D.H. Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors. Proc. Natl. Acad. Sci. USA. 2004 101:3527-3532.
  • Lodoen, M., Ogasawara, K., Hamerman, J.A., Arase, H., Houchins, J.P., Mocarski, E.S., and Lanier, L.L. NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules. J. Exp. Med. 2003 197:1245-1253.
  • Arase, H., Mocarski, E.S., Campbell, A.E., Hill, A.B., Lanier, L.L. Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors. Science 2002 296:1323-1326.
  • Yokosuka, T., Takase, K., Suzuki, M., Nakagawa, Y., Taki, S., Takahashi, H., Fujisawa, T., Arase, H. and Saito, T. Predominant role of TCRα chain in forming pre-immune TCR repertoire revealed by clonal TCR reconstitution system. J. Exp. Med. 2002 195:1-12.
  • Arase, H., Saito, T., Phillips, J. H. and Lanier, L. L. The mouse NK cell-associated antigen recognized by DX5 mAb is CD49b (α2 integrin, VLA-2). J. Immunol. 2001 167: 1141-1144.
  • Arase, H., Suenaga, T., Arase, N., Kimura, Y., Ito, K., Shiina, R., Ohno, H. and Saito, T. Negative regulation of expression and function of FcγRIII by CD3ζ in murine NK cells. J. Immunol. 2001 166:21-25.
  • Arase, K., Saijo, K., Watanabe, H., Konno, A., Arase, H., and Saito, T. Ablation of a specific cell population by the replacement of an uniquely expressed gene with a toxin gene. Proc. Natl. Acad. Sci. USA 1999 96: 9264-9268.
  • Arase, N., Arase, H., Park, S. Y., Ohno, H., Ra, C., and Saito, T. Association with FcRγ is essential for activation signal through NKR-P1 (CD161) in natural killer (NK) cells and NK1.1+ T cells. J. Exp. Med. 1997 186:1957-1963.(First two authors equally contributed)
  • Saijo, K., Park, S.Y., Ishida, Y., Arase, H., and Saito, T. Crucial role of Jak3 in negative selection of self-reactive T cells. J. Exp. Med. 1997 185:351-356.
  • Arase, H., Arase, N., and Saito, T. Interferon gamma production by natural killer (NK) cells and NK1.1+ T cells upon NKR-P1 cross-linking. J. Exp. Med. 1996 183:2391-2396.
  • Arase, H., Ono, S., Arase, N., Park, S. Y., Wakizaka, K., Watanabe, H., Ohno, H., and Saito, T. Developmental arrest of NK1.1+ T cell antigen receptor (TCR)-α/β+ T cells and expansion of NK1.1+ TCR-γ/δ+ T cell development in CD3ζ-deficient mice. J. Exp. Med. 1995 182:891-895.
  • Arase, H., Arase, N., and Saito, T. Fas-mediated cytotoxicity by freshly isolated natural killer cells. J. Exp. Med. 1995 181:1235-1238.1.
  • Park, S. Y., Saijo, K., Takahashi, T., Osawa, M., Arase, H., Hirayama, N., Miyake, K., Nakauchi, H., Shirasawa, T., and Saito, T. Developmental defects of lymphoid cells in Jak3 kinase-deficient mice. Immunity 1995 3:771-782.
  • Arase, H.., Arase, N., Kobayashi, Y., Nishimura, Y., Yonehara, S., and Onoe, K. Cytotoxicity of fresh NK1.1+ T cell receptor α/β+ thymocytes against a CD4+8+ thymocyte population associated with intact Fas antigen expression on the target. J. Exp. Med. 1994 180:423-432.
  • Arase, H., Arase, N., Ogasawara, K., Good, R.A., and Onoe, K. An NK1.1+ CD4+8- single-positive thymocyte subpopulation that expresses a highly skewed T-cell antigen receptor Vβ family. Proc. Natl. Acad. Sci. USA. 1992 89:6506-6510.

総 説

  • Arase, H., and Lanier, L.L. Specific recognition of virus-infected cells by paired NK receptors. Rev. Med. Virol. 2004 14:83-93.
  • Arase, H., and Lanier, L.L. Virus-driven evolution of natural killer cell receptors. Microbes Infect. 2002 4:1505-1512.
  • [学会発表]