免疫化学分野

大阪大学 免疫学フロンティア研究センター 免疫化学研究室 / 微生物病研究所 免疫化学分野

Original Papers (After 2000)

    2017

  • Furukawa A, Kakita K, Yamada T, Ishizuka M, Sakamoto J, Hatori N, Maeda N, Ohsaka F, Saitoh T, Nomura T, Kuroki K, Nambu H, Arase H, Matsunaga S, Anada M, Ose T, Hashimoto S, Maenaka K. 2017. Structural and thermodynamic analyses reveal critical features of glycopeptide recognition by the human PILRα immune cell receptor. J. Biol. Chem. in press [Link]
  • Dai HS, Griffin N, Bolyard C, Mao HC, Zhang J, Cripe TP, Suenaga T, Arase H, Nakano I, Chiocca EA, Kaur B, Yu J, Caligiuri MA. 2017. The Fc Domain of Immunoglobulin Is Sufficient to Bridge NK Cells with Virally Infected Cells. Immunity. 47:159-170.e10. [Link]
  • Hiwa R, Ohmura K, Arase N, Jin H, Hirayasu K, Kohyama M, Suenaga T, Saito F, Terao C, Atsumi T, Iwatani H, Mimori T, Arase H. 2017. Myeloperoxidase/HLA class II complexes recognized by autoantibodies in microscopic polyangiitis. Arthritis Rheumatol. 69:2069-2080. [Link]
  • Arase N, Tanimura K, Jin H, Yamaoka T, Kishibe M, Nishioka M, Kiyohara E, Tani M, Matsuoka S, Ohmura K, Takasugi K, Yamamoto T, Murota H, Arase H, Katayama I. 2017. Novel autoantibody against the β2-glycoprotein I/HLA-DR complex in patients with refractory cutaneous ulcers. Br. J. Dermatol. 83:157-159.
    [Link]

    2016

  • Hirayasu K, Saito F, Suenaga T, Shida K, Arase N, Oikawa K, Yamaoka T, Murota H, Chibana H, Nagai H, Nakamura Y, Katayama I, Colonna M, Arase H. 2016. LILRA2 is an innate immune sensor for microbially cleaved immunoglobulins. Nat. Microbiol. 1 :16054. [Link]
  • Kohyama, M., Matsuoka, S., Shida, K., Sugihara, F., Aoshi, T., Kishida, K., Ishii, K.J., Arase, H. 2016. Monocyte infiltration into obese and fibrilized tissues is regulated by PILRα. Eur. J. Immunol. 46:1214-1223. [Link]

    2015

  • Arase, H. 2015. Rheumatoid Rescue of Misfolded Cellular Proteins by MHC Class II Molecules: A New Hypothesis for Autoimmune Diseases Adv. Immunol. 129:1-23. [Link]
  • Arase, N., Arase, H. 2015. Cellular misfolded proteins rescued from degradation by MHC class II molecules are possible targets for autoimmune diseases. J. Biochem. 158:367-372. [Link]
  • Suenaga, T., Matsumoto, M., Arisawa, F., Kohyama, M., Hirayasu, K., Mori, Y., Arase, H. 2015. Sialic acids on varicella-zoster virus glycoprotein B required for cell-cell fusion J. Biol. Chem. 290:19833-19843. [Link]
  • Watson, R.L., Buck, J., Levin, L.R., Winger, R.C., Wang, J., Arase, H. Muller, W.A. 2015. Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration. J Exp Med. 212:1021-1041. [Link]
  • Hirayasu, K., Arase, H. 2015. Functional and genetic diversity of leukocyte immunoglobulin-like receptor and implication for disease associations. J Hum Genet. 60:703-708. [Link]

  • Tanimura, K., Jin, H, Suenaga, T., Morikami, S., Arase, N., Kishida, K., Hirayasu, K., Kohyama, M., Ebina, Y., Yasuda, S., Horita, T., Takasugi, K., Ohmura, K., Yamamoto, K., Katayama, I., Sasazuki, T., Lanier. L. L., Atsumi, T., Yamada, H. and Arase, H. 2015. β2-glycoprotein I / HLA class II complexes are novel autoantigens in antiphospholipid syndrome. Blood. 125: 2835-2844. [Link]

  • Kishida, K., Kohyama, M., Kurashima, Y., Kogure, Y., Wang, J., Hirayasu, K., Suenaga, T., Kiyono, H., Kunisawa, J., Arase, H. 2015. Negative regulation of DSS-induced experimental colitis by PILR. Int. Immunol. 27: 307-314.[Link]

    2014

  • Suenaga, T., Kohyama, M., Hirayasu, K., Arase, H. 2014. Engineering large viral DNA genomes using the CRISPR-Cas9 system. Microbiol Immunol. 58:513-522.[Link]
  • Deng, M., Lu, Z., Zheng, J., Wan, X., Chen, X., Hirayasu, K., Sun, H., Lam, Y., Chen, L., Wang, Q., Song, C., Huang, N., Gao, F. G., Jiang, Y., Arase, H., and Zhang, C. 2014. A motif in LILRB2 critical for Angptl2 binding and activation. Blood. 124:924-935. [Link]
  • Kuroki, K., Wang, J., Ose, T., Yamaguchi, M., Tabata, S., Maita, N., Nakamura, S., Kajikawa, M., Kogure, A., Satoh, T., Arase, H. and Maenaka, K. 2014. Structural basis for simultaneous recognition of an O-glycan and its attached peptide of mucin family by immune receptor PILRα. Proc. Natl. Acad. Sci. USA. 111:8877-8882. [Link]
  • Wang, J., Arase, H. Regulation of immune responses by neutrophils. 2014. Ann. N. Y. Acad. Sci. 1319:66-81. [Link]
  • Jin, H., Arase, N., Hirayasu, K., Kohyama, M., Suenaga, T., Saito, F., Tanimura, K., Matsuoka, S., Ebina, K., Shi, K., Toyama-Sorimachi, N., Yasuda, S., Horita, T., Hiwa, R., Takasugi, K., Ohmura, K., Yoshikawa, H., Saito, T., Atsumi, T., Sasazuki, T., Katayama, I., L. Lanier, L., and Arase, H. Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility. 2014. Proc. Natl. Acad. Sci. USA. 111: 3787-3792. [Link]
  • Haldar, M., Kohyama, M., So, A.Y., Kc, W., Wu X, Briseño, C.G., Satpathy, A.T., Kretzer, N.M., Arase, H., Rajasekaran, N.S., Wang, L., Egawa, T., Igarashi, K., Baltimore, D., Murphy, T.L., Murphy, K.M. 2014. Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages. Cell 156:1223-1234. [Link]
  • 2013

  • Minami, T., Kijima, T.,Kohmo, S., Arase, H., Otani, Y., Nagatomo, I., Takahashi, R., Miyake, K., Higashiguchi, M., Morimura, O., Ihara, S., Tsujino, K., Hirata, K., Inoue, K., Takeda, Y., Kida, H., Tachibana, I., Kumanogoh, A. 2013. Overcoming chemoresistance of small-cell lung cancer through stepwise HER2-targeted antibody-dependent cell-mediated cytotoxicity and VEGF-targeted antiangiogenesis. Sci Rep. 3:2669. [Link]
  • Imai, T., Koyanagi, N., Ogawa, R., Shindo, K., Suenaga, T., Sato, A., Arii, J., Kato, A., Kiyono, H., Arase, H., Kawaguchi, Y. 2013. Us3 Kinase encoded by Herpes Simplex Virus 1 Mediates Downregulation of Cell Surface Major Histocompatibility Complex Class I and Evasion of CD8+ T cells. PLoS One. 8:e72050. [Link]
  • Tanaka, Y., Suenaga, T., Matsumoto, M., Seya, T., Arase, H. 2013. Herpesvirus 6 Glycoproteins B (gB), gH, gL and gQ are Necessary and Sufficient for Cell-to-Cell Fusion. J. Virol. 87:10900-10903. [Link]
  • Arase, N., Wataya-Kaneda, M., Oiso, N., Arase, H., Katayama, I. 2013.CD1a-positive familial cutaneous mastocytosis without germ-line or somatic mutations in c-kit. Br J Dermatol. 169:201-204. [Link]
  • Jiang, Y., Arase, N., Kohyama, M., Hirayasu, K., Suenaga, T., Jin, H., Matsumoto, M., Shida, K., L. Lanier, L., Saito, T. and Arase, H. 2013. Transport of misfolded endoplasmic reticulum proteins to the cell surface by MHC class II molecules. Int. Immunol. 25:235-246. [Link]
  • Wang, J., Shiratori, I., Uehori, J., Ikawa, M., Arase, H. 2013. Neutrophil infiltration during inflammation is regulated by PILRα via modulation of integrin activation. Nat. Immunol. 14:34-40. [Link]

    2012

  • Ihara, S., Kida, H., Arase, H., Tripathi, L.P., Chen, Y.A., Kimura, T., Yoshida, M., Kashiwa, Y., Hirata, H., Fukamizu, R., Inoue, R., Hasegawa, K., Goya, S., Takahashi, R., Minami, T., Tsujino, K., Suzuki, M., Kohmo, S., Inoue, K., Nagatomo, I., Takeda, Y., Kijima, T., Mizuguchi, K., Tachibana, I., Kumanogoh, A. 2012. Inhibitory Roles of Signal Transducer and Activator of Transcription 3 in Antitumor Immunity during Carcinogen-Induced Lung Tumorigenesis. Cancer Res. 72:2990-2999. [Link]
  • Hirayasu, K., Ohashi, J., Kashiwase, K., Hananantachai, H., Naka, I., Ogawa, A., Takanashi, M., Satake, M., Nakajima, K., Parham, P., Arase, H., Tokunaga, K., Patarapotikul, J., Yabe, T. 2012. Significant Association of KIR2DL3-HLA-C1 Combination with Cerebral Malaria and Implications for Co-evolution of KIR and HLA. PLoS Pathog. 8:e1002565. [Link]
  • Yamaji, O., Nagaishi, T., Totsuka, T., Onizawa, M., Suzuki, M., Tsuge, N., Hasegawa, A., Okamoto, R., Tsuchiya, K., Nakamura, T., Arase, H., Kanai, T., Watanabe, M. 2012. The Development of Colitogenic CD4+ T Cells Is Regulated by IL-7 in Collaboration with NK Cell Function in a Murine Model of Colitis. J. Immunol. 188:2524-2536.[Link]
  • 2011

  • Kogure, A., Shiratori, I., Wang, J., L. Lanier, L.,Arase, H. 2011. PANP is a novel O-glycosylated PILRα ligand expressed in neural tissues. Biochem Biophys Res Commun 405:428-433.[Link]
  • 2010

  • Arii, J., Goto, H., Suenaga, T., Oyama, M., Kozika-Hata, H., Imai, T., Minowa, A., Akashi, H., Arase, H., Kawaoka, Y., and Kawaguchi, Y. 2010. Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1. Nature 467:859-862.[Link]
  • Arii, J., Wang, J., Morimoto, T., Suenaga, T., Akashi, H., Arase, H., and Kawaguchi, Y. 2010. A Single Amino Acid Substitution in Herpes simplex virus 1 Envelope Glycoprotein B at a Site Required for Binding to the Paired Immunoglobulin-like Type 2 Receptor α(PILRα) Abrogates PILRα-dependent Viral Entry and Reduces Pathogenesis. J. Virol. 84:10773-10783.[Link]
  • Suenaga, T., Satoh, T., Somboonthum, P., Kawaguchi, Y., Mori, Y., and Arase, H. 2010. Myelin-associated glycoprotein mediates membrane fusion and entry of neurotropic herpesviruses. Proc. Natl. Acad. Sci. USA 107:866-871.[Link]
  • Li, L., Fang, C.J., Ryan, J.C., Niemi, E.C., Lebron, J.A., Bjorkman, P.J., Arase, H.,, Torti, F.M., Torti, S.V., Nakamura, M.C., Seaman, W.E. 2010. Binding and uptake of H-ferritin are mediated by human transferrin receptor-1. Proc. Natl. Acad. Sci. USA 107:3505-3510.[Link]
  • 2009

  • Wang, J., Fan, Q., Satoh, T., Arii, J., Lanier, L.L., Spear, P.G., Kawaguchi, Y., Arase, H. 2009. Binding of herpes simplex virus glycoprotein B (gB) to PILRα depends on specific sialylated O-linked glycans on gB J. Virol. 83:13042-13045.[Link]
  • Arase, H., and Seino, K.I. 2009. The study of regulatory T cells and NKT cells in Japan: a historical perspective. Int. Immunol 21:1101-1103.[Link]
  • Arii, J., Uema, M., Morimoto, T., Sagara, H., Akashi, H., Ono, E., Arase, H., and Kawaguchi, Y. 2009. Entry of herpes simplex virus 1 and other alphaherpesviruses via the paired immunoglobulin-like type 2 receptor α. J. Virol. 83:4520-4527.[Link]
  • Fan, Q., Lin, E., Satoh, T., Arase, H., and Spear, P.G. 2009. Differential effects on cell fusion activity of mutations in herpes simplex virus 1 glycoprotein B (gB) dependent on whether a gD receptor or a gB receptor is overexpressed. J. Virol. 83:7384-7390.[Link]
  • Kato, A., Arii, J., Shiratori, I., Akashi, H., Arase, H., and Kawaguchi, Y. 2009. Herpes simplex virus 1 protein kinase Us3 phosphorylates viral envelope glycoprotein B and regulates its expression on the cell surface. J. Virol. 83:250-261.[Link]
  • Orr, M.T., Sun, J.C., Hesslein, D.G., Arase, H., Phillips, J.H., Takai, T., and Lanier, L.L. 2009. Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection. J. Exp. Med. 206:807-817.[Link]
  • Toma-Hirano, M., Namiki, S., Shibata, Y., Ishida, K., Arase, H., Miyatake, S., Arai, K., and Kamogawa-Schifter, Y. 2009. Ly49Q ligand expressed by activated B cells induces plasmacytoid DC maturation. Eur. J. Immunol. 39:1344-1352.[Link]
  • 2008

  • Liang, S., Ristich, V., Arase, H., Dausset, J., Carosella, E.D. and Horuzsko, A. 2008. Modulation of dendritic cell differentiation by HLA-G and ILT4 requires the IL-6-STAT3 signaling pathway. Proc. Natl. Acad. Sci. USA. 105:8357-8362. [Link]
  • Mizui, M., Shikina, T., Arase, H., Suzuki, K., Yasui, T., Rennert, P.D., Kumanogoh, A., and Kikutani, H. 2008. Bimodal regulation of T cell-mediated immune responses by TIM-4. Int. Immunol. 20:695-708.[Link]
  • Satoh, T., Arii, J., Suenaga, T., Wang, J., Kogure, A., Uehori, J., Arase, N., Shiratori, I., Tanaka, S., Kawaguchi, Y., Spear, P.G., Lanier, L.L. and Arase, H. 2008. PILRα is a herpes simplex virus-1 entry co-receptor that associates with glycoprotein B. Cell 132:935-944.[Link]
  • Tabata, S., Kuroki, K., Wang, J., Kajikawa, M., Shiratori, I., Kohda, D., Arase, H. and Maenaka, K. 2008. Biophysical characterization of O-glycosylated CD99 recognition by paired Ig-like type 2 receptors (PILR) J. Biol. Chem. 283: 8893-8901.[Link]
  • Wang, J., Shiratori, I., Satoh, T., Lanier, L.L., and Arase, H. 2008. An essential role of sialylated O-linked sugar chains in the recognition of mouse CD99 by paired immunoglobulin-like type 2 receptor (PILR). J. Immunol. 180:1686-1693. [Link]
  • Tabata, S., Kuroki, K., Maita, N., Wang, J., Shiratori, I., Arase, H., Kohda, D., and Maenaka, K. 2008. Expression, crystallization and preliminary x-ray diffraction analysis of human paired Ig-like type 2 receptor α(PILRα). Acta. Cryst. 64:44-46. [Link]
  • 2007

  • Suenaga, T., Arase, H., Yamasaki, S., Kohno, M., Yokosuka, T., Takeuchi, A., Hattori, T., and Saito, T. 2007. Cloning of B-cell-specific tetramembrane spanning molecule BTS possessing B cell proliferation inhibitory function. Eur. J. Immunol. 37:3197-3207. [Link]
  • Adams, E. J., Juo, Z. S., Venook, R. T., Boulanger, M. J., Arase, H., Lanier, L. L., and Garcia, K. C. 2007. Structural elucidation of the m157 mouse cytomegalovirus ligand for Ly49 natural killer cell receptors. Proc. Natl. Acad. Sci. USA. 104:10128-10133. [Link]
  • Carr, W. H., Rosen, D. B., Arase, H., Nixon, D. F., Michaelsson, J., and Lanier, L. L. 2007. KIR3DS1, a gene implicated in resistance to progression to AIDS, encodes a DAP12-associated receptor expressed on NK cells that triggers NK cell activation. J. Immunol. 178:647-651. [Link]
  • 2006

  • Shiroishi, M., Kuroki, K., Ose, T., Rasubala, L., Shiratori, I., Arase, H., Tsumoto, K., Kumagai, I., Kohda, D., Maenaka, K. 2006. Efficient leukocyte IG-like receptor signaling and crystal structure of disulfide-linked HLA-G dimer. J. Biol. Chem. 281:10439-10447. [Link]
  • 2005

  • Shiratori, I., Yamaguchi, M., Suzukawa, M., Yamamoto, K., Lanier, L.L., Saito, T. and Arase, H. 2005. Downregulation of basophil function by human CD200 and human herpesvirus-8 CD200. J. Immunol. 175:4441-4449. [Link]
  • Arase, N., Takeuchi, A., Unno, M., Hirano, S., Yokosuka, T., Arase, H. and Saito, T. 2005. Heterotypic interaction of CRTAM with Necl2 induces cell adhesion on activated NK cells and CD8+ T cells. Int. Immunol. 17:1227-1237. [Link]
  • 2004

  • Ishikawa, S., Arase, N., Suenaga, T., Saita, Y., Noda, M., Kuriyama, T., Arase, H., and Saito, T. 2004. Involvement of FcRγ in signal transduction of osteoclast-associated receptor (OSCAR). Int. Immunol. 16:1019-1025. [Link]
  • Shiratori, I., Ogasawara, K., Saito, T., Lanier, L. L., and Arase, H. 2004. Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor. J. Exp. Med. 199:525-533. [Link]
  • Ohtsuka, M., Arase, H., Takeuchi, A., Yamasaki, S., Shiina, R., Sakurai, D., Arase, N., Suenaga, T., Iwashima, M., Kitamura, T., Moriya, H., and Saito, T. 2004. NFAM1, a new ITAM+ cell surface molecule that regulates development and signaling of B lymphocytes. Proc. Natl. Acad. Sci. USA. 101: 8126-8131 (First two authors equally contributed). [Link]
  • Arase, H., and Lanier, L.L. Specific recognition of virus-infected cells by paired NK receptors. Rev. Med. Virol. 2004 14:83-93. [Link]
  • Carlyle, J.R., Jamieson, A.M., Gasser, S., Clingan, C.S., Arase, H., and Raulet, D.H. 2004. Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors. Proc. Natl. Acad. Sci. USA. 101:3527-3532. [Link]
  • Sakurai, D., Yamasaki, S., Arase, K., Park, S.Y., Arase, H., Konno, A., and Saito, T. 2004. FcεRIγ-ITAM is differentially required for mast cell function in vivo. J. Immunol. 172:2374-2381. [Link]
  • 2003

  • Lodoen, M., Ogasawara, K., Hamerman, J.A., Arase, H., Houchins, J.P., Mocarski, E.S., and Lanier, L.L. 2003. NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules. J. Exp. Med. 197:1245-1253. [Link]
  • Arase, N., Arase, H., Hirano, S., Yokosuka, T., Sakurai, D., and Saito, T. 2003. IgE-mediated activation of NK cells through FcγRIII. J. Immunol. 170:3054-3058. [Link]
  • 2002

  • Arase, H., Mocarski, E.S., Campbell, A.E., Hill, A.B., Lanier, L.L. 2002. Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors. Science 296:1323-1326. [Link]
  • Arase, H., Lanier, L.L. (2002) Virus-driven evolution of NK cell receptors. Microbes Infect. 4:1505-1512. [Link]
  • Itoh, K., Sakakibara, M., Yamasaki, S., Takeuchi, A., Arase, H., Miyazaki, M., Nakajima, N., Okada, M. and Saito, T. 2002. Negative regulation of immune synapse formation by anchoring lipid raft to cytoskeleton through Cbp-EBP50-ERM assembly. J. Immunol. 168:541-544. [Link]
  • Yokosuka, T., Takase, K., Suzuki, M., Nakagawa, Y., Taki, S., Takahashi, H., Fujisawa, T., Arase, H. and Saito, T. 2002. Predominant role of TCRα chain in forming pre-immune TCR repertoire revealed by clonal TCR reconstitution system. J. Exp. Med. 195:1-12. [Link]
  • 2001

  • Arase, H., Saito, T., Phillips, J. H. and Lanier, L. L. 2001. The mouse NK cell-associated antigen recognized by DX5 mAb is CD49b (α2 integrin, VLA-2). J. Immunol. 167: 1141-1144. [Link]
  • Arase, H., Suenaga, T., Arase, N., Kimura, Y., Ito, K., Shiina, R., Ohno, H. and Saito, T. 2001. Negative regulation of expression and function of FcγRIII by CD3ζ in murine NK cells. J. Immunol. 166:21-25. [Link]
  • Tomita, K., Saijo, K., Yamasaki, S., Iida, T., Nakatsu, F., Arase, H., Ohno, H., Shirasawa, T., Kuriyama, T., O'Shea, J. J. and Saito, T. 2001. Cytokine-independent Jak3 activation upon TCR stimulation through direct association of Jak3 and the TCR complex. J. Biol. Chem. 276: 25378-25385. [Link]
  • Takeuchi, A., Yamasaki, S., Takase, K., Nakatsu, F., Arase, H., Onodera, M. and Saito, T. 2001. E2A and HEB activate the pre-TCRα promoter during immature T cell development. J. Immunol. 167:2157-2163 [Link].
  • 2000

  • Hamano, Y., Arase, H., Saisho, H. and Saito, T. 2000. Immune complex and Fc receptor-mediated augmentation of antigen presentation for in vivo helper T cell responses. J. Immunol. 164:6113-6119. [Link]
  • Nakatsu, F., Sakuma, M., Matsuo, Y., Arase, H., Yamasaki, S., Nakamura, N., Saito, T. and Ohno, H. 2000. A di-leucine signal in the ubiquitin moiety: possible involvement in ubiquitination-mediated endocytosis. J. Biol. Chem. 275:26213-26219. [Link]
  • Iida, T., Ohno, H., Nakaseko, C., Sakuma, M., Takeda-Ezaki, M., Arase, H., Kominami, E., Fujisawa, T. and Saito, T. 2000. Regulation of cell surface expression of CTLA-4 by secretion of CTLA-4-containing lysosomes upon activation of CD4+ T cells. J. Immunol. 165:5062-5068. [Link]
  • Watanabe, N., Arase, H., Onodera, M., Ohashi, P. and Saito, T. 2000. The quantity of TCR signaling determines positive selection and commitment of T cells. J. Immunol. 165:6252-6261. [Link]