Mechanism of autoimmunity / Host-pathogen interaction

• Mori S, Kohyama M, Yasumizu Y, Tada A, Tanzawa K, Shishido T, Kishida K, Jin H, Nishide M, Kawada S, Motooka D, Okuzaki D, Naito R, Nakai W, Kanda T, Murata T, Terao C, Ohmura K, Arase N, Kurosaki T, Fujimoto M, Suenaga T, Kumanogo A, Sakaguchi S, Ogawa Y, Arase H

  Neoself-antigens are the primary target for autoreactive T cells in human lupus.
  Cell  2024 10.1016/j.cell.2024.08.025 [Link] [Free Link] (until November 02, 2024)

• Jin H, Kishida K, Arase N,Matsuoka S, Nakai W, Kohyama M, Suenaga T, Yamamoto K, Sasazuki T, Arase H

  Abrogation of self-tolerance by misfolded self-antigens complexed with MHC class II molecules.
  Science Advances 8:eabj9867 2022. [Link]

• Liu Y, Soh WT, Kishikawa J, Hirose M, Nakayama EE, Li S, Sasai M, Suzuki T, Tada A, Arakawa A, Matsuoka S, Akamatsu K, Matsuda M, Ono C, Torii S, Kishida K, Jin H, Nakai W, Arase N, Nakagawa A, Matsumoto M, Nakazaki Y, Shindo Y, Kohyama M, Tomii K, Ohmura K, Ohshima S, Okamoto T, Yamamoto M, Nakagami H, Matsuura Y, Nakagawa A, Kato T, Okada M, Standley DM, Shioda T, Arase H

  An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies.
  Cell 184:3452-3466 2021. [Link]

• Harrison TE, Mørch AM, Felce JH, Sakoguchi A, Reid AJ, Arase H, Dustin ML, Higgins MK

  Structural basis for RIFIN-mediated activation of LILRB1 in malaria.
  Nature 587: 309–312 2020. [Link]

• Saito F, Hirayasu k, Satoh T, Wang CW, Lusingu J, Arimori T, Shida K, Palacpac NMQ, Itagaki S, Iwanaga S, Takashima E, Tsuboi T, Kohyama M, Suenaga T, Colonna M, Takagi J, Lavstsen T, Horii T, Arase H.

  Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors.
  Nature 552:101–105 2017. [HTML Link] [PDF link]

• Hirayasu K, Saito F, Suenaga T, Shida K, Arase N, Oikawa K, Yamaoka T, Murota H, Chibana H, Nagai H, Nakamura Y, Katayama I, Colonna M, Arase H.

  LILRA2 is an innate immune sensor for microbially cleaved immunoglobulins.
  Nature Microbiology 1 :16054. 2016. [Link]

• Jin, H., Arase, N., Hirayasu, K., Kohyama, M., Suenaga, T., Saito, F., Tanimura, K., Matsuoka, S., Ebina, K., Shi, K., Toyama-Sorimachi, N., Yasuda, S., Horita, T., Hiwa, R., Takasugi, K., Ohmura, K., Yoshikawa, H., Saito, T., Atsumi, T., Sasazuki, T., Katayama, I., L. Lanier, L., and Arase, H.

  Autoantibodies to IgG/HLA-DR complexes are associated with rheumatoid arthritis susceptibility.
  Proc. Natl. Acad. Sci. USA. 111: 3787-3792. 2014. [Link]

• Wang, J., Shiratori, I., Uehori, J., Ikawa, M., Arase, H.

  Neutrophil infiltration during inflammation is regulated by PILRα via modulation of integrin activation.
  Nature Immunology 14:34-40. 2013 [Link]

• Suenaga, T., Satoh, T., Somboonthum, P., Kawaguchi, Y., Mori, Y., and Arase, H.

  Myelin-associated glycoprotein mediates membrane fusion and entry of neurotropic herpesviruses.
  Proc. Natl. Acad. Sci. USA 107:866-871. 2010.[Link]

• Satoh, T., Arii, J., Suenaga, T., Wang, J., Kogure, A., Uehori, J., Arase, N., Shiratori, I., Tanaka, S., Kawaguchi, Y., Spear, P.G., Lanier, L.L. and Arase, H.

  PILRα is a herpes simplex virus-1 entry co-receptor that associates with glycoprotein B.
  Cell 132:935-944. 2008 [Link]

• Shiratori, I., Ogasawara, K., Saito, T., Lanier, L. L., and Arase, H.

  Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor.
  J. Exp. Med. 199:525-533. 2004 [Link]

• Arase, H., Mocarski, E.S., Campbell, A.E., Hill, A.B., Lanier, L.L.

  Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors.
  Science 296:1323-1326. 2002 [Link]

• Arase, N., Arase, H., Park, S. Y., Ohno, H., Ra, C., and Saito, T.

  Association with FcRγ is essential for activation signal through NKR-P1 (CD161) in natural killer (NK) cells and NK1.1+ T cells.
  J. Exp. Med. 186:1957-1963. 1997. (First two authors equally contributed) [Link]

• Arase, H., Arase, N., and Saito, T.

  Interferon γ production by natural killer (NK) cells and NK1.1+ T cells upon NKR-P1 cross-linking.
  J. Exp. Med. [Link]183:2391-2396. 1996.

• Arase, H., Ono, S., Arase, N., Park, S. Y., Wakizaka, K., Watanabe, H., Ohno, H., and Saito, T.

  Developmental arrest of NK1.1+ T cell antigen receptor (TCR)-α/β+ T cells and expansion of NK1.1+ TCR-γ/δ+ T cell development in CD3ζ-deficient mice.
  J. Exp. Med. 182:891-895. 1995 [Link]

• Arase, H., Arase, N., and Saito, T.

  Fas-mediated cytotoxicity by freshly isolated natural killer cells.
  J. Exp. Med. 181:1235-1238. 1995 [Link]

• Arase, H.., Arase, N., Kobayashi, Y., Nishimura, Y., Yonehara, S., and Onoe, K.

  Cytotoxicity of fresh NK1.1+ T cell receptor α/β+ thymocytes against a CD4+8+ thymocyte population associated with intact Fas antigen expression on the target.
  J. Exp. Med. 180:423-432. 1994 [Link]

• Arase, H., Arase, N., Nakagawa, K., Good, R. A., and Onoe K.

  NK1.1+ CD4+CD8- thymocytes with specific lymphokine secretion.
  Eur. J. Immunol. 23: 307-310. 1993 [Link]

• Arase, H., Arase, N., Ogasawara, K., Good, R.A., and Onoe, K.

  An NK1.1+ CD4+8- single-positive thymocyte subpopulation that expresses a highly skewed T-cell antigen receptor Vβ family.
  Proc. Natl. Acad. Sci. USA. 89:6506-6510. 1992 [Link]

• Jin H, Arase H.

  Neoself Antigens Presented on MHC Class II Molecules in Autoimmune Diseases.
  Adv Exp Med Biol.  2024 1444:51-65. [Link]

• Arase H.

  The major histocompatibility complex: new insights from old molecules into the pathogenesis of autoimmunity.
  Int Immunol.  2021 33:641-645. [Link]

• Arase, H.

  Rheumatoid Rescue of Misfolded Cellular Proteins by MHC Class II Molecules: A New Hypothesis for Autoimmune Diseases
  Adv. Immunol. 129:1-23. 2015 [Link]

• Arase, N., Arase, H.

  Cellular misfolded proteins rescued from degradation by MHC class II molecules are possible targets for autoimmune diseases.
  J. Biochem. 158:367-372. 2015 [Link]

• Arase, H., and Lanier, L.L.

  Specific recognition of virus-infected cells by paired NK receptors.
  Rev. Med. Virol. 2004 14:83-93.

• Arase, H., and Lanier, L.L.

  Virus-driven evolution of natural killer cell receptors.
  Microbes Infect. 2002 4:1505-1512.