When this defense system fails, the body is unable to protect itself from infectious diseases, autoimmune diseases, and allergies develop. Therefore, it is no exaggeration to say that the immune system has evolved together with pathogens, and it is very important to elucidate "how the immune system is regulated and plays a role in biological defense" and "how the immune system interacts with pathogens".

In fact, many immune diseases caused by immune disorders are triggered by some kind of infection, but the molecular mechanisms remain unclear.

Therefore, our laboratory is investigating why the immune system, which has evolved to protect the body from infectious diseases, is triggered by infectious diseases.

We focus on various regulatory molecules of immune cells and investigate how they regulate immune responses by interacting with biomolecules, how they are involved in defense and pathogenicity by interacting with pathogens, and the molecular mechanisms of why self-tolerance of the immune system is disrupted by infection and other causes. We are investigating the molecular mechanisms of how the immune response is regulated by interactions with pathogens, and why self-tolerance of the immune system is disrupted by infection, using methods such as genetically engineered mice, single cell analysis, RNAseq, receptor-ligand interactions, and gene library screening.

We believe that these studies will lead not only to the elucidation of the immune response to infectious diseases, but also to the elucidation of the pathogenic mechanisms of many diseases and the development of therapeutic strategies.