Publication

2026

• Kishida K, Kawakami K, Tanabe H, Nakai W, Yonekura K, Yokoyama S, Arase H.

  Immune-induced TCR-like antibodies regulate specific T cell response in mice

  Nature Communications  2026 17: 3227. [Link]

• Ono Y, Ota H, Ogi M, Fukushi Y, Wada S, Arase H, Yoshino O, Yamada H.

  Uterine Endometrial Microbiome and Chronic Endometritis in Relation to Anti-β2-Glycoprotein I (β2GPI)/Human Leukocyte Antigen (HLA)-DR Autoantibodies in Women With Recurrent Implantation Failure and Recurrent Pregnancy Loss: A Cross-Sectional Study

  Reproductive Medicine and Biology  2026 25: e70049. [Link]

• Yamada H, Ono Y, Ota H, Kobayashi Y, Fukushi Y, Wada S, Arase H.

  Anti-β2GPI/HLA-DR Antibody, Chronic Endometritis, and Uterine Endometrial Microbiome in Women with Recurrent Pregnancy Loss: A Prospective Cohort Study

  Microorganisms  2026 14: 544. [Link]

• Wang J, Furukawa A, Chen L, Suzuki R, Arase H, Hirayasu K, Maenaka K.

  Molecular basis of fibrinogen recognition by the innate immune receptor LILRA2

  Journal of Biological Chemistry  2026 302: 111276. [Link]

2025

• Ono Y, Wada S, Kobayashi Y, Ogi M, Fukushi Y, Tanimura K, Arase H, Yoshino O, Yamada H.

  Pregnancy outcomes in women with anti-β2-glycoprotein I/human leukocyte antigen-DR autoantibodies receiving assisted reproductive technology: a prospective cohort study

  Frontiers in Immunology  2025 16: 1626862. [Link]

• De CK, Tsuda M, Zhu C, Dehn S, Hinrichs H, Tsuji N, Jin H, Arase H, Tanaka S, List B.

  The Overlooked Stereoisomers of the Ionizable Lipid ALC315

  Journal of the American Chemical Society  2025 147: 28595-28600. [Link]

• Higuchi S, Liu Y, Shimizu J, Ono C, Itoh Y, Nakai W, Jin H, Kishida K, Takayama K, Okamoto T, Murakami Y, Kinoshita T, Matsuura Y, Shioda T, Arase H.

  Evolutionary dynamics of heparan sulfate utilization by SARS-CoV-2

  mBio  2025 e0130325. [Link]  [AI Podcast]

• Sakoguchi A, Chamberlain SG, Mørch AA, Widdess M, Harrison TE, Dustin ML, Arase H^*, Higgins MK^*, Iwanaga S^{* *}Corresponding authors.

  RIFINs displayed on malaria-infected erythrocytes bind KIR2DL1 and KIR2DS1

  Nature  2025 s41586-025-09091-y [Link]  [AI Podcast]

  This is a paper that reveals the possibility that the human natural killer (NK) cell receptor KIR and the malaria parasite Plasmodium falciparum have co-evolved. In our previous studies, we elucidated that the P. falciparumuses a molecule called RIFIN to suppress the host's immune response (Saito et al., Nature 2017; Harrison et al., Nature2020). However, it has long been a mystery why the KIR gene family includes not only "inhibitory KIRs", which suppress the immune system, but also "activating KIRs", which activate it. In this study, we first discovered that the malaria parasite's RIFIN binds to the inhibitory receptor KIR2DL1 with a tenfold higher affinity than its natural host ligand, HLA-C. Furthermore, we found that the activating receptor KIR2DS1 also recognizes this RIFIN, leading to the activation of NK cells against infected red blood cells. These findings suggest a "co-evolutionary" scenario: in response to the malaria parasite acquiring a mechanism to evade immunity by exploiting inhibitory KIRs, humans evolved activating KIRs to detect and counteract this, thereby gaining a new defense mechanism against infection. This research reveals the possibility that the diversity of the KIR genes was shaped by the selective pressure of malaria, providing important insights into unraveling the history of how the host immune system has evolved in conjunction with infectious diseases.

2024

• Mori S, Kohyama M, Yasumizu Y, Tada A, Tanzawa K, Shishido T, Kishida K, Jin H, Nishide M, Kawada S, Motooka D, Okuzaki D, Naito R, Nakai W, Kanda T, Murata T, Terao C, Ohmura K, Arase N, Kurosaki T, Fujimoto M, Suenaga T, Kumanogo A, Sakaguchi S, Ogawa Y, Arase H

  Neoself-antigens are the primary target for autoreactive T cells in human lupus

  Cell  2024 187: 6071-6087 [Link]  [AI Podcast]

  This paper overturns conventional concept in immunology by discovering that T cells can distinguish between normally presented "self-peptides" and abnormally presented "neoself" on MHC class II molecules. In immunology, it has long been believed that MHC class II molecules present peptides to T cells. However, when the expression of the invariant chain, which is necessary for peptide presentation by MHC class II molecules, is reduced, misfolded proteins from within the cell are presented on MHC class II molecules instead. We refer to these self-antigens, which are not normally presented by MHC class II molecules, as "neoself." By establishing a mouse model where MHC dysfunction could be induced to generate neoself, we discovered that T cells recognize these neoself self-antigens as foreign and attack them, leading to the development of systemic autoimmune disease. Furthermore, we found that approximately 10% of the abnormally activated T cells in patients with Systemic Lupus Erythematosus (SLE), a systemic autoimmune disease, also recognize this neoself. While most adults are persistently infected with the Epstein-Barr virus (EBV), it has been reported that a high frequency of its reactivation increases the risk of developing SLE. This study elucidates for the first time a mechanism for autoimmune disease development driven by persistent viral reactivation. We demonstrate that repeated EBV reactivation causes MHC dysfunction, resulting in the generation of neo-self that in turn activates self-reactive T cells in SLE patients.

• Kuratani A, Okamoto M, Kishida K, Okuzaki D, Sasai M, Sakaguchi S, Arase H, Yamamoto M

  Platelet factor 4-induced TH1-Treg polarization suppresses antitumor immunity

  Science  2024 386: eadn8608. [Link]

• Jin H, Arase H

  Neoself Antigens Presented on MHC Class II Molecules in Autoimmune Diseases

  Adv Exp Med Biol  2024 1444: 51-65. [Link]

• Tanimura K, Saito S, Tsuda S, Ono Y, Deguchi M, Nagamatsu T, Fujii T, Nakatsuka M, Kobashi G, Arase H, Yamada H

  Low-dose aspirin and heparin treatment improves pregnancy outcome in recurrent pregnancy loss women with anti-β2-glycoprotein I/HLA-DR autoantibodies: a prospective, multicenter, observational study

  Front Immunol.  2024 15: 1445852. [Link]  [AI Podcast]

• Li Y, Hirayasu K, Hasegawa G, Tomita Y, Hashikawa Y, Hiwa R, Arase H, Hanayama R

  Fibrinogen induces inflammatory responses via the immune activating receptor LILRA2

  Front Immunol.  2024 15: 1435236. [Link]

2023

• Naito R, Ohmura K, Higuchi S, Nakai W, Kohyama M, Mimori T, Morinobu A, Arase H

  Positive and negative regulation of the Fcγ receptor-stimulating activity of RNA-containing immune complexes by RNase

  JCI Insight  2023 8:e167799 [Link]

• Ozono T, Kimura Y, Suenaga T, Beck G, Jinno J, Aguirre C, Ikenaka K, Krainc D, Mochizuki H, Arase H

  Extracellular transportation of α-synuclein by HLA class II molecules

  Biochem Biophys Res Commun  2023 644: 25-33. [Link]  [AI Podcast]

• Tanimura K, Saito S, Tsuda S, Ono Y, Ota H, Wada S, Deguchi M, Nakatsuka M, Nagamatsu T, Fujii T, Kobashi G, Arase H, Yamada H

  Anti-β2-glycoprotein I/HLA-DR Antibody and Adverse Obstetric Outcomes

  Int J Mol Sci  2023. 24:10958 [Link]

• Kohyama M, Suzuki T, Nakai W, Ono C, Matsuoka S, Iwatani K, Liu Y, Sakai Y, Nakagawa A, Tomii K, Ohmura K, Okada M, Matsuura Y, Ohshima S, Maeda Y, Okamoto T, Arase H

  SARS-CoV-2 ORF8 is a viral cytokine regulating immune responses

  Int Immunol  2023 35: 43–52 [Link]

• Urano E, Itoh Y, Suzuki T, Sasaki T, Kishikawa J I, Akamatsu K, Higuchi Y, Sakai Y, Okamura T, Mitoma S, Sugihara F, Takada A, Kimura M, Nakao S, Hirose M, Sasaki T, Koketsu R, Tsuji S, Yanagida S, Shioda T, Hara E, Matoba S, Matsuura Y, Kanda Y, Arase H, Okada M, Takagi J, Kato T, Hoshino A, Yasutomi Y, Saito A, Okamoto T

  An inhaled ACE2 decoy confers protection against SARS-CoV-2 infection in preclinical models

  Science Translational Medicine  2023 15: eadi2623 [Link]

• Ono Y, Wada S, Ota H, Fukushi Y, Tanimura K, Yoshino O, Arase H, Yamada H

  Anti-β2-glycoprotein I/HLA-DR antibody in infertility

  J Reprod Immunol  2023. 158: 103955 [Link]

• Yoneda K, Ueda Y, Tanimura K, Arase H, Yamada H, and Saegusa J

  Association of anti-β2-glycoprotein I/HLA-DR complex antibody with arterial thrombosis in female patients with systemic rheumatic diseases

  Arthritis Res Ther.  2023 25: 195. [Link]

• Zhang S, Tsuji H, Jin H, Kitagori K, Akizuki S, Nakashima R, Yoshifuji H, Tanaka M, Arase H, Ohmura K, Morinobu A

  Rheumatoid factor recognizes specific domains of the IgG heavy chain complexed with HLA class II molecules

  Rheumatology (Oxford)  2023. 62: 3151-3155 [Link]

• Kusano S, Ueda S, Oryoji D, Toyoumi A, Hashimoto-Tane A, Kishi H, Hamana H, Muraguchi A, Jin H, Arase H, Miyadera H, Kishikawa R, Yoshikai Y, Yamada H, Yamamoto K, Nishimura Y, Saito T, Sasazuki T, Yokoyama S

  Contributions of the N-terminal flanking residues of an antigenic peptide from the Japanese cedar pollen allergen Cry j 1 to the T-cell activation by HLA-DP5

  Int Immunol  2023. 35: 447-458 [Link]

2022

• Jin H, Kishida K, Arase N, Matsuoka S, Nakai W, Kohyama M, Suenaga T, Yamamoto K, Sasazuki T, Arase H

  Abrogation of self-tolerance by misfolded self-antigens complexed with MHC class II molecules.

  Science Advances  2022. 8:eabj9867 [Link]

• Suenaga T , Mori Y, Suzutani T, Arase H

  Regulation of Siglec-7-mediated varicella-zoster virus infection of primary monocytes by cis-ligands

  Biochem Biophys Res Commun  2022. DOI: 10.1016/j.bbrc.2022.04.111 [Link]

• Suenaga T , Mori Y, Suzutani T, Arase H

  Siglec-7 mediates varicella-zoster virus infection by associating with glycoprotein B

  Biochem Biophys Res Commun  2022. 607: 67-72 [Link]

• Sakoguchi A, Arase H

  Mechanisms for Host Immune Evasion Mediated byPlasmodium falciparum-Infected Erythrocyte Surface Antigens

  Front Immunol  2022. 13:901864. [Link]

• Ng KW, Faulkner N, Finsterbusch K, Wu M, Harvey R, Hussain S, Greco M, Liu Y, Kjaer S, Swanton C, Gandhi S, Beale R, Gamblin SJ, Cherepanov P, McCauley J, Daniels R, Howell M, Arase H, Wack A, Bauer DLV, Kassiotis G

  SARS-CoV-2 S2-targeted vaccination elicits broadly neutralizing antibodies

  Science Translational Medicine  2022. 14:eabn3715 [Link]

• Arase N, Tsuji H, Takamatsu H, Jin H, Konaka H, Hamaguchi Y, Tonomura K, Kotobuki Y, Ueda-Hayakawa I, Matsuoka S, Hirano T, Yorifuji H, Murota H, Ohmura K, Nakashima R, Sato T, Kumanogoh A, Katayama I, Arase H, Fujimoto M.

  Cell surface-expressed Ro52/IgG/HLA-DR complex is targeted by autoantibodies in patients with inflammatory myopathies.

  J Autoimmun.  2022 126:102774. [Link]

• Zhao P, Xu Y, Jiang L, Fan X, Li L, Li X, Arase H, Zhao Y, Cao W, Zheng H, Xu H, Tong Q, Zhang N, An Z.

  A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer's disease

  Science Translational Medicine  2022. 14:eabq009 [Link]

• Hayashi H, Sun J, Yanagida Y, Otera T, Kubota-Koketsu R, Shioda T, Ono C, Matsuura Y, Arase H, Yoshida S, Nakamaru R, Ju N, Ide R, Tenma A, Kawabata S, Ehara T, Sakaguchi M, Tomioka H, Shimamura M, Okamoto S, Amaishi Y, Chono H, Mineno J, Komatsuno T, Saito Y, Rakugi H, Morishita R, Nakagami H.

  Preclinical study of a DNA vaccine targeting SARS-CoV-2

  Curr Res Transl Med  2022. 14:eabq009 [Link]

• Adachi Y, Sakai T, Terakura S, Shiina T, Suzuki S, Hamana H, Kishi H, Sasazuki T, Arase H, Hanajiri R, Goto T, Nishida T, Murata M, Kiyoi H.

  Downregulation of HLA class II is associated with relapse after allogeneic stem cell transplantation and alters recognition by antigen-specific T cells.

  Int J Hematol.  2022 115:371-381 [Link]

• Beppu S, Kinoshita M, Wilamowski J, Suenaga T, Yasumizu Y, Ogawa K, Ishikura T, Tada S, Koda T, Murata H, Shiraishi N, Sugiyama Y, Kihara K, Sugimoto T, Arase H, Standley DM, Okuno T, Mochizuki H.

  High cell surface expression and peptide binding affinity of HLA-DQA1*05:03, a susceptible allele of neuromyelitis optica spectrum disorders (NMOSD).

  Sci Rep.  2022. 12:106. [Link]

• Shimizu Y, Kotobuki Y, Arase N, Arase H, Katayama I, Fujimoto M.

  A Case of Pretibial Epidermolysis Bullosa with Novel Mutations of the COL7A1 Gene.

  Ann Dermatol.  2022 34:81-83. [Link]

• Kimura I, Kosugi Y, Wu J, Zahradnik J, Yamasoba D, Butlertanaka EP, Tanaka YL, Uriu K, Liu Y, Morizako N, Shirakawa K, Kazuma Y, Nomura R, Horisawa Y, Tokunaga K, Ueno T, Takaori-Kondo A, Schreiber G, Arase H ; Genotype to Phenotype Japan (G2P-Japan) Consortium, Motozono C, Saito A, Nakagawa S, Sato K.

  The SARS-CoV-2 Lambda variant exhibits enhanced infectivity and immune resistance.

  Cell Rep.   2022 38:110218 [Link]

• Tsuji, H, Ohmura, K, Jin, H, Naito, R, Arase, N, Kohyama, K, Suenaga, T, Sakakibara, S, Kochi, Y, Okada, Y, Yamamoto, K, Kikutani, H, Morinobu, A, Mimori, T, Arase H

  Anti-dsDNA antibodies recognize DNA presented on HLA class II molecules of systemic lupus erythematosus risk alleles.

  Arthritis Rheumatol  2022 74:105-111.[Link]

2021

• Liu Y, Soh WT, Kishikawa J, Hirose M, Nakayama EE, Li S, Sasai M, Suzuki T, Tada A, Arakawa A, Matsuoka S, Akamatsu K, Matsuda M, Ono C, Torii S, Kishida K, Jin H, Nakai W, Arase N, Nakagawa A, Matsumoto M, Nakazaki Y, Shindo Y, Kohyama M, Tomii K, Ohmura K, Ohshima S, Okamoto T, Yamamoto M, Nakagami H, Matsuura Y, Nakagawa A, Kato T, Okada M, Standley DM, Shioda T, Arase H

  An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies.

  Cell  2021 184:3452-3466 [Link]

• Liu Y, Arase N, Kishikawa J-i, Hirose M, Li S, Tada A, Matsuoka S, Arakawa A, Akamatsu K, Ono C, Jin H, Kishida K, Nakai W, Kohyama M, Nakagawa A, Yamagishi Y, Nakagami H, Kumanogoh A, Matsuura Y, Standley DM, Kato T, Okada M, Fujimoto M, Arase H

  The SARS-CoV-2 Delta variant is poised to acquire complete resistance to wild-type spike vaccines.

  bioRxiv  doi:10.1101/2021.08.22.457114: [Link]

• Sakoguchi A, Saito F, Hirayasu K, Shida K, Matsuoka S, Itagaki S, Nakai W, Kohyama M, Suenaga T, Iwanaga S, Horii T, Arase H.

  Plasmodium falciparum RIFIN is a novel ligand for inhibitory immune receptor LILRB2.

  Biochem Biophys Res Commun  2021 548:167-173. [Link]

• Matsumoto Y, Kishida K, Matsumoto M, Matsuoka S, Kohyama M,Suenaga T, Arase H.

  A TCR-like antibody against a proinsulin-containing fusion peptide ameliorates type 1 diabetes in NOD mice

  Biochem Biophys Res Commun  2021 534:680-686. [Link]

• Arase H

  The major histocompatibility complex: new insights from old molecules into the pathogenesis of autoimmunity.

  Int Immunol.  2021 33:641-645. [Link]

• Wu G, Xu Y, Schultz RD, Chen H, Xie J, Deng M, Liu X, Gui X, John S, Lu Z, Arase H, Zhang N, An Z, Zhang CC.

  LILRB3 supports acute myeloid leukemia development and regulates T-cell antitumor immune responses through the TRAF2-cFLIP-NF-κB signaling axis.

  Nature Cancer  2021 2:1170-1184. [Link]

• Yamashita C, Arase N, Higuchi S, Arase H, Takagi J, Nojima S, Tanemura A, Fujimoto M.

  Serum autoantibodies against the extracellular region of α6β4 integrin in a patient with dipeptidyl peptidase-4 inhibitor-induced bullous pemphigoid.

  JAAD Case Rep.  2021 20:65-68.[Link]

• Lu X, Hosono Y, Nagae M, Ishizuka S, Ishikawa E, Motooka D, Ozaki Y, Sax N, Maeda Y, Kato Y, Morita T, Shinnakasu R, Inoue T, Onodera T, Matsumura T, Shinkai M, Sato T, Nakamura S, Mori S, Kanda T, Nakayama EE, Shioda T, Kurosaki T, Takeda K, Kumanogoh A, Arase H, Nakagami H, Yamashita K, Takahashi Y, Yamasaki S.

  Identification of conserved SARS-CoV-2 spike epitopes that expand public cTfh clonotypes in mild COVID-19 patients.

  J Exp Med  2021 218:e20211327 [Link]

• Yoshida S, Ono C, Hayashi H, Fukumoto S, Shiraishi S, Tomono K, Arase H, Matsuura Y, Nakagami H.

  SARS-CoV-2-induced humoral immunity through B cell epitope analysis in COVID-19 infected individuals.

  Sci Rep.  2021 11:5934 [Link]

• Su MT, Inui M, Wong YL, Takahashi M, Sugahara-Tobinai A, Ono K, Miyamoto S, Murakami K, Itoh-Nakadai A, Kezuka D, Itoi S, Endo S, Hirayasu K, Arase H, Takai T.

  Blockade of checkpoint ILT3/LILRB4/gp49B binding to fibronectin ameliorates autoimmune disease in BXSB/Yaa mice.

  Int Immunol.  2021 33:447-458 [Link]

2020

• Liu Y, Soh WT, Tada A, Arakawa A, Matsuoka S, Nakayama EE, Li S, Ono C, Torii S, Kishida K, Jin H, Nakai W, Arase N, Nakagawa A, Shindo Y, Kohyama M, Nakagami H, Tomii K, Ohmura K, Ohshima S, Okada M, MatsuuraY, Standley DM, Shioda T, Arase H

  An infectivity-enhancing site on the SARS-CoV-2 spike protein is targeted by COVID-19 patient antibodies.

  bioRxiv  2020.12.18.423358; doi: https://doi.org/10.1101/2020.12.18.423358. [Link]

• Soh WT, Liu Y, Nakayama EE, Ono C, Torii S, Nakagami H, MatsuuraY, Shioda T, Arase H

  The N-terminal domain of spike glycoprotein mediates SARS-CoV-2 infection by associating with L-SIGN and DC-SIGN.

  bioRxiv  2020.11.05.369264; doi: https://doi.org/10.1101/2020.11.05.369264 [Link]

• Chen H, Chen Y, Deng M, John S, Gui X, Kansagra A, Chen W, Kim J, Lewis C, Wu G, Xie J, Zhang L, Huang R, Liu X, Arase H , Huang Y, Yu H, Luo W, Xia N, Zhang N, An Z, Zhang CC.

  Antagonistic anti-LILRB1 monoclonal antibody regulates antitumor functions of natural killer cells.

  J. Immunother. Cancer.  2020 8:e000515. [Link]

• Harrison TE, Mørch AM, Felce JH, Sakoguchi A , Reid AJ, Arase H, Dustin ML, Higgins MK.

  Structural basis for RIFIN-mediated activation of LILRB1 in malaria.

  Nature.   2020 587: 309–312 [Link]

• Tanimura K, Saito S, Nakatsuka M, Nagamatsu T, Fujii T, Fukui A, Deguchi M, Sasagawa Y, Arase N, Arase H, Yamada H.

  The β2-Glycoprotein I/HLA-DR Complex As A Major Autoantibody Target in Obstetric Antiphospholipid Syndrome.

  Arthritis. Rheumatol.  2020 587:309-312. [Link]

• Yamazaki R, Furukawa A, Hirayasu K, Yumoto K, Fukuhara H, Arase H, Maenaka K.

  Molecular mechanism of the recognition of bacterially cleaved immunoglobulin by the immune regulatory receptor LILRA2.

  J. Biol. Chem.  2020 295:9531-9541. [Link]

• Arase N, Wataya-Kaneda M, Murota H, Nakagawa Y, Yamaoka T, Itoi-Ochi S, Hirayasu K, Arase H, Fujimoto M, Katayama I.

  Genotype and phenotype analysis of patients with pediatric cutaneous mastocytosis, especially wild-type KIT patients.

  J. Dermatol.  2020 47:426-429. [Link]

• Takeshita M, Suzuki K, Kaneda Y, Yamane H, Ikeura K, Sato H, Kato S, Tsunoda K, Arase H, Takeuchi T.

  Antigen-driven selection of antibodies against SSA, SSB and the centromere 'complex', including a novel antigen, MIS12 complex, in human salivary glands.

  Ann. Rheum. Dis.  2020 79:150-158. [Link]

2019

• Maekawa A, Arase N, Tamai K, Nomura T, Kiyohara E, Wataya-Kaneda M, Arase H, Katayama I, Fujimoto M.

  Case of epidermolytic ichthyosis with impairment of pulmonary function and exacerbated skin manifestations in a late middle-aged adult.

  J. Dermatol.   2019. 46:e480-e482. [Link]

• Arase N, Tanemura A, Jin H, Nishioka M, Aoyama Y, Oiso N, Matsunaga K, Suzuki T, Nishigori C, Kawamura T, Shimizu T, Ito A, Fukai K, Abe Y, Yang L, Tsuruta D, Takeoka K, Iwatani Y, Hidaka Y, Nishida M, Yamauchi-Takihara K, Arase H, Fujimoto M, Katayama I.

  Autoantibodies detected in patients with vitiligo vulgaris but not in those with rhododendrol-induced leukoderma.

  J. Dermatol. Sci.  2019. 95:80-83. [Link]

• Yorifuji H, Arase N, Kohyama M, Hirano T, Suenaga T, Kumanogoh A, Arase H.

  Transport of cellular misfolded proteins to the cell surface by HLA-B27 free heavy chain.

  Biochem. Biophys. Res. Commun.  2019. 511:862-868. [Link]

• Shimizu Y, Kohyama M, Yorifuji H, Jin H, Arase N, Suenaga T, Arase H.

  FcγRIIIA-mediated activation of NK cells by IgG heavy chain complexed with MHC class II molecules.

  Int Immunol. 2019. 31:303-314. [Link]

• Shishido T, Kohyama M, Nakai W, Matsumoto M, Miyata H, Suenaga T, Arase H

  Invariant chain p41 mediates production of soluble MHC class II molecules.

  Biochem. Biophys. Res. Commun. 2019. 509:216-221. [Link]

2018

• Chen HM, van der Touw W, Wang YS, Kang K, Mai S, Zhang J, Alsina-Beauchamp D, Duty JA, Mungamuri SK, Zhang B, Moran T, Flavell R, Aaronson S, Hu HM, Arase H, Ramanathan S, Flores R, Pan PY, Chen SH.

  Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity.

  J. Clin. Invest. 2018 128:5647-5662. [Link]

• Deng M, Gui X, Kim J, Xie L, Chen W, Li Z, He L, Chen Y, Chen H, Luo W, Lu Z, Xie J, Churchill H, Xu Y, Zhou Z, Wu G, Yu C, John S, Hirayasu K, Nguyen N, Liu X, Huang N, Li L, Deng H, Tang H, Sadek HA, Zhang L, Huang T, ZouY, Chen B, Zhu H, Arase H , Xia N, Jiang Y, Collins R, You JM, Homsi J, Unni N, Lewis C, Chen GQ, Fu YX, Liao CX, An Z, Zheng J, Zhang N, Zhang CC.

  LILRB4 signaling in leukemia cells mediates T cell suppression and tumor infiltration.

  Nature 2018 562:605-609. [Link]

• Kayama H, Kohyama M, Okuzaki D, Motooka D, Barman S, Okumura R, Muneta M, Hoshino K, Sasaki I, Ise W, Matsuno H, Nishimura J, Kurosaki T, Nakamura S, Arase H, Kaisho T, Takeda K.

  Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles.

  Proc Natl Acad Sci USA. 2018 115:8418-8423. [Link]

2017

• Saito F, Hirayasu K, Satoh T, Wang CW, Lusingu J, Arimori T, Shida K, Palacpac NMQ, Itagaki S, Iwanaga S, Takashima E, Tsuboi T, Kohyama M, Suenaga T, Colonna M, Takagi J, Lavstsen T, Horii T, Arase H

  Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors.

  Nature 2017 552:101–105 [HTML Link] [PDF link]

• Furukawa A, Kakita K, Yamada T, Ishizuka M, Sakamoto J, Hatori N, Maeda N, Ohsaka F, Saitoh T, Nomura T, Kuroki K, Nambu H, Arase H, Matsunaga S, Anada M, Ose T, Hashimoto S, Maenaka K.

  Structural and thermodynamic analyses reveal critical features of glycopeptide recognition by the human PILRα immune cell receptor.

  J. Biol. Chem.  2017 292:21128-21136. [Link]

• Dai HS, Griffin N, Bolyard C, Mao HC, Zhang J, Cripe TP, Suenaga T, Arase H, Nakano I, Chiocca EA, Kaur B, Yu J, Caligiuri MA.

  The Fc Domain of Immunoglobulin Is Sufficient to Bridge NK Cells with Virally Infected Cells.

  Immunity.  2017 47:159-170.e10. [Link]

• Hiwa R, Ohmura K, Arase N, Jin H, Hirayasu K, Kohyama M, Suenaga T, Saito F , Terao C, Atsumi T, Iwatani H, Mimori T, Arase H.

  Myeloperoxidase/HLA class II complexes recognized by autoantibodies in microscopic polyangiitis.

  Arthritis Rheumatol.  2017 69:2069-2080. [Link]

• Arase N, Tanimura K, Jin H, Yamaoka T, Kishibe M, Nishioka M, Kiyohara E, Tani M, Matsuoka S, Ohmura K, Takasugi K, Yamamoto T, Murota H, Arase H, Katayama I.

  Novel autoantibody against the β2-glycoprotein I/HLA-DR complex in patients with refractory cutaneous ulcers.

  Br. J. Dermatol.  2017 83:157-159. [Link]

  各種自己抗体が陰性で原因不明の難治性皮膚潰瘍の患者さんの約３割にβ２グライコプロテインI／HLAクラスII複合体に対する自己抗体が陽性になることが判明した。 従って、原因不明の皮膚潰瘍の患者さんの原因として抗リン脂質抗体症候群が関与している可能性が明らかになった。 HLAクラスII分子によって形成された「ネオセルフ」を用いることによって、今まで検出できなかった自己抗体も検出できるようになることから、 免疫疾患の診断上でも有用であることが判明した。

2016

• Hirayasu K, Saito F, Suenaga T, Shida K, Arase N, Oikawa K, Yamaoka T, Murota H, Chibana H, Nagai H, Nakamura Y, Katayama I, Colonna M, Arase H.

  LILRA2 is an innate immune sensor for microbially cleaved immunoglobulins.

  Nature Microbiology 2016. 1 :16054. [Link]

• Kohyama M, Matsuoka S, Shida K, Sugihara F, Aoshi T, Kishida K, Ishii KJ, Arase H

  Monocyte infiltration into obese and fibrilized tissues is regulated by PILRα.

  Eur. J. Immunol. 2016. 46:1214-1223. [Link]

2015

• Arase H 2015. Rheumatoid Rescue of Misfolded Cellular Proteins by MHC Class II Molecules: A New Hypothesis for Autoimmune Diseases

  Adv. Immunol.  129:1-23. [Link]

• Arase N, Arase H 2015. Cellular misfolded proteins rescued from degradation by MHC class II molecules are possible targets for autoimmune diseases.

  J. Biochem.  158:367-372. [Link]

• Suenaga T, Matsumoto M, Arisawa F, Kohyama M, Hirayasu K, Mori Y, Arase H 2015. Sialic acids on varicella-zoster virus glycoprotein B required for cell-cell fusion

  J. Biol. Chem.  290:19833-19843. [Link]

• Watson RL, Buck J, Levin LR, Winger RC, Wang J, Arase H, Muller WA. 2015. Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.

  J Exp Med.  212:1021-1041. [Link]

• Hirayasu K, Arase H 2015. Functional and genetic diversity of leukocyte immunoglobulin-like receptor and implication for disease associations.

  J Hum Genet.   60:703-708. [Link]

• Tanimura K, Jin, H, Suenaga T, Morikami S, Arase N, Kishida K, Hirayasu K, Kohyama, M. , Ebina Y, Yasuda S, Horita T, Takasugi K, Ohmura K, Yamamoto K, Katayama I, Sasazuki T, Lanier LL, Atsumi T, Yamada, H. Arase H 2015. β2-glycoprotein I / HLA class II complexes are novel autoantigens in antiphospholipid syndrome.

  Blood.   125: 2835-2844. [Link]

• Kishida K, Kohyama M, Kurashima Y, Kogure Y, Wang J, Hirayasu K, Suenaga T, Kiyono H, Kunisawa J, Arase H 2015. Negative regulation of DSS-induced experimental colitis by PILR.

  Int. Immunol.   27: 307-314.[Link]

2014

• Jin H, Arase N, Hirayasu K, Kohyama M, Suenaga T, Saito F, Tanimura K, Matsuoka, S. , Ebina K, Shi K, Toyama-Sorimachi N, Yasuda S, Horita T, Hiwa R, Takasugi K, Ohmura K, Yoshikawa H, Saito T, Atsumi T, Sasazuki T, Katayama I, Lanier LL, Arase H 2014. Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility.

  Proc. Natl. Acad. Sci. USA.   111: 3787-3792. [Link]

• Suenaga T, Kohyama M, Hirayasu K, Arase H 2014. Engineering large viral DNA genomes using the CRISPR-Cas9 system.

  Microbiol Immunol.  58:513-522. [Link]

• Deng M, Lu Z, Zheng J, Wan X, Chen X, Hirayasu K, Sun H, Lam Y, Chen L, Wang Q, Song C, Huang N, Gao FG, Jiang Y, Arase H, Zhang C. 2014. A motif in LILRB2 critical for Angptl2 binding and activation.

  Blood.   124:924-935. [Link]

• Kuroki K, Wang J, Ose T, Yamaguchi M, Tabata S, Maita N, Nakamura S, Kajikawa M, Kogure A, Satoh T, Arase H, Maenaka K. 2014. Structural basis for simultaneous recognition of an O-glycan and its attached peptide of mucin family by immune receptor PILRα.

  Proc. Natl. Acad. Sci. USA.   111:8877-8882. [Link]

• Wang J, Arase H Regulation of immune responses by neutrophils. 2014.

  Ann. N. Y. Acad. Sci.   1319:66-81. [Link]

• Haldar M, Kohyama M, So AY, Kc W, Wu X, Briseño CG, Satpathy AT, Kretzer NM, Arase H, Rajasekaran NS, Wang L, Egawa T, Igarashi K, Baltimore D, Murphy TL, Murphy KM. 2014. Heme-Mediated SPI-C Induction Promotes Monocyte Differentiation into Iron-Recycling Macrophages.

  Cell  156:1223-1234. [Link]

2013

• Jiang Y, Arase N, Kohyama M, Hirayasu K, Suenaga T, Jin H, Matsumoto M, Shida K, L. Lanier LL, Saito T, Arase H 2013. Transport of misfolded endoplasmic reticulum proteins to the cell surface by MHC class II molecules.

  Int. Immunol.   25:235-246. [Link]

• Wang J, Shiratori I, Uehori J, Ikawa M, Arase H 2013. Neutrophil infiltration during inflammation is regulated by PILRα via modulation of integrin activation.

  Nat. Immunol.   14:34-40. [Link]

• Tanaka Y, Suenaga T, Matsumoto M, Seya T, Arase H 2013. Herpesvirus 6 Glycoproteins B (gB), gH, gL and gQ are Necessary and Sufficient for Cell-to-Cell Fusion.

  J. Virol.   87:10900-10903. [Link]

• Arase N, Wataya-Kaneda M, Oiso N, Arase H, Katayama, I. 2013.CD1a-positive familial cutaneous mastocytosis without germ-line or somatic mutations in c-kit.

  Br J Dermatol.   169:201-204. [Link]

• Minami T, Kijima T,Kohmo S, Arase H, Otani Y, Nagatomo I, Takahashi R, Miyake K, Higashiguchi M, Morimura O, Ihara S, Tsujino K, Hirata K, Inoue K, Takeda Y, Kida H, Tachibana I, Kumanogoh A. 2013. Overcoming chemoresistance of small-cell lung cancer through stepwise HER2-targeted antibody-dependent cell-mediated cytotoxicity and VEGF-targeted antiangiogenesis.

  Sci Rep.   3:2669. [Link]

• Imai T, Koyanagi N, Ogawa R, Shindo K, Suenaga T, Sato A, Arii J, Kato A, Kiyono H, Arase H, Kawaguchi Y. 2013. Us3 Kinase encoded by Herpes Simplex Virus 1 Mediates Downregulation of Cell Surface Major Histocompatibility Complex Class I and Evasion of CD8⁺ T cells.

  PLoS One.   8:e72050. [Link]

2012

• Ihara S, Kida H, Arase H, Tripathi LP, Chen YA, Kimura T, Yoshida M, Kashiwa Y, Hirata H, Fukamizu R, Inoue R, Hasegawa K, Goya S, Takahashi R, Minami T, Tsujino K, Suzuki M, Kohmo S, Inoue K, Nagatomo I, Takeda Y, Kijima T, Mizuguchi K, Tachibana I, Kumanogoh A. 2012. Inhibitory Roles of Signal Transducer and Activator of Transcription 3 in Antitumor Immunity during Carcinogen-Induced Lung Tumorigenesis.

  Cancer Res.   72:2990-2999. [Link]

• Hirayasu K, Ohashi J, Kashiwase K, Hananantachai H, Naka I, Ogawa A, Takanashi M, Satake M, Nakajima K, Parham P, Arase H, Tokunaga K, Patarapotikul J, Yabe T. 2012. Significant Association of KIR2DL3-HLA-C1 Combination with Cerebral Malaria and Implications for Co-evolution of KIR and HLA.

  PLoS Pathog.  8:e1002565. [Link]

• Yamaji O, Nagaishi T, Totsuka T, Onizawa M, Suzuki M, Tsuge N, Hasegawa A, Okamoto R, Tsuchiya K, Nakamura T, Arase H, Kanai T, Watanabe M. 2012. The Development of Colitogenic CD4⁺ T Cells Is Regulated by IL-7 in Collaboration with NK Cell Function in a Murine Model of Colitis.

  J. Immunol.  188：2524-2536.[Link]

2011

• Kogure A, Shiratori I, Wang J, Lanier LL. Arase H 2011. PANP is a novel O-glycosylated PILRα ligand expressed in neural tissues.

  Biochem Biophys Res Commun  405:428-433.[Link]

2010

• Suenaga T, Satoh T, Somboonthum P, Kawaguchi Y, Mori Y, Arase H 2010. Myelin-associated glycoprotein mediates membrane fusion and entry of neurotropic herpesviruses.

  Proc. Natl. Acad. Sci. USA  107:866-871.[Link]

• Arii J, Goto H, Suenaga T, Oyama M, Kozika-Hata H, Imai T, Minowa A, Akashi H, Arase H, Kawaoka Y, Kawaguchi, Y. 2010. Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1.

  Nature  467:859-862.[Link]

• Arii J, Wang J, Morimoto T, Suenaga T, Akashi H, Arase H, Kawaguchi Y. 2010. A Single Amino Acid Substitution in Herpes simplex virus 1 Envelope Glycoprotein B at a Site Required for Binding to the Paired Immunoglobulin-like Type 2 Receptor α(PILRα) Abrogates PILRα-dependent Viral Entry and Reduces Pathogenesis.

  J. Virol.  84:10773-10783.[Link]

• Li L, Fang CJ, Ryan JC, Niemi EC, Lebron JA, Bjorkman PJ, Arase H, Torti FM, Torti SV, Nakamura MC, Seaman, W.E. 2010. Binding and uptake of H-ferritin are mediated by human transferrin receptor-1.

  Proc. Natl. Acad. Sci. USA  107:3505-3510.[Link]

2009

• Wang J, Fan Q, Satoh T, Arii J, Lanier LL, Spear PG, Kawaguchi Y, Arase H 2009. Binding of herpes simplex virus glycoprotein B (gB) to PILRα depends on specific sialylatedO-linked glycans on gB

  J. Virol.  83:13042-13045.[Link]

• Arase H, Seino KI 2009. The study of regulatory T cells and NKT cells in Japan: a historical perspective.

  Int. Immunol  21:1101-1103.[Link]

• Arii J, Uema M, Morimoto T, Sagara H, Akashi H, Ono E, Arase H, Kawaguchi Y. 2009. Entry of herpes simplex virus 1 and other alphaherpesviruses via the paired immunoglobulin-like type 2 receptor α.

  J. Virol  . 83:4520-4527.[Link]

• Fan Q, Lin E, Satoh T, Arase H, Spear PG 2009. Differential effects on cell fusion activity of mutations in herpes simplex virus 1 glycoprotein B (gB) dependent on whether a gD receptor or a gB receptor is overexpressed.

  J. Virol  . 83:7384-7390.[Link]

• Kato A, Arii J, Shiratori I, Akashi H, Arase H, Kawaguchi Y 2009. Herpes simplex virus 1 protein kinase Us3 phosphorylates viral envelope glycoprotein B and regulates its expression on the cell surface.

  J. Virol  . 83:250-261.[Link]

• Orr MT, Sun JC, Hesslein DG, Arase H, Phillips JH, Takai T, Lanier LL. 2009. Ly49H signaling through DAP10 is essential for optimal natural killer cell responses to mouse cytomegalovirus infection.

  J. Exp. Med  . 206:807-817.[Link]

• Toma-Hirano M, Namiki S, Shibata Y, Ishida K, Arase H, Miyatake S, Arai K, Kamogawa-Schifter Y. 2009. Ly49Q ligand expressed by activated B cells induces plasmacytoid DC maturation.

  Eur. J. Immunol  . 39:1344-1352.[Link]

2008

• Satoh T, Arii J, Suenaga T, Wang J, Kogure A, Uehori J, Arase N, Shiratori I, Tanaka S, Kawaguchi Y, Spear PG, Lanier LL, Arase H 2008. PILRα is a herpes simplex virus-1 entry co-receptor that associates with glycoprotein B.

  Cell  132:935-944.[Link]

• Wang J, Shiratori I, Satoh T, Lanier LL, Arase H 2008. An essential role of sialylated O-linked sugar chains in the recognition of mouse CD99 by paired immunoglobulin-like type 2 receptor (PILR).

  J. Immunol.  180:1686-1693. [Link]

  PILRは免疫細胞の発現する抑制化レセプターであるが、リガンドの認識機構は明らかでなかった。 本論文ではリガンド蛋白質上の特定のO型糖鎖修飾がPILRの認識に必須であることを明らかにした。 つまり、PILRはリガンド分子上の特定のアミノ酸配列と糖鎖修飾の双方を認識するユニークなレセプターであることが明らかになった。

• Liang S, Ristich V, Arase H, Dausset J, Carosella ED, Horuzsko A. 2008. Modulation of dendritic cell differentiation by HLA-G and ILT4 requires the IL-6-STAT3 signaling pathway.

  Proc. Natl. Acad. Sci. USA.  105:8357-8362. [Link]

• Mizui M, Shikina T, Arase H, Suzuki K, Yasui T, Rennert PD, Kumanogoh A, Kikutani H. 2008. Bimodal regulation of T cell-mediated immune responses by TIM-4.

  Int. Immunol.  20:695-708.[Link]

• Tabata S, Kuroki K, Wang J, Kajikawa M, Shiratori I, Kohda D, Arase H, Maenaka K. 2008. Biophysical characterization of O-glycosylated CD99 recognition by paired Ig-like type 2 receptors (PILR)

  J. Biol. Chem.  283: 8893-8901.[Link]

• Tabata S, Kuroki K, Maita N, Wang J, Shiratori I, Arase H, Kohda D, Maenaka K. 2008. Expression, crystallization and preliminary x-ray diffraction analysis of human paired Ig-like type 2 receptor α (PILRα).

  Acta. Cryst.   64:44-46. [Link]

2007

• Suenaga T, Arase H, Yamasaki S, Kohno M, Yokosuka T, Takeuchi A, Hattori T, Saito T. 2007. Cloning of B-cell-specific tetramembrane spanning molecule BTS possessing B cell proliferation inhibitory function.

  Eur. J. Immunol.  37:3197-3207. [Link]

• Adams EJ, Juo ZS, Venook RT, Boulanger MJ, Arase H, Lanier LL, Garcia KC. 2007. Structural elucidation of the m157 mouse cytomegalovirus ligand for Ly49 natural killer cell receptors.

  Proc. Natl. Acad. Sci. USA.  104:10128-10133. [Link]

• Carr WH, Rosen DB, Arase H, Nixon DF, Michaelsson J, and Lanier LL. 2007. KIR3DS1, a gene implicated in resistance to progression to AIDS, encodes a DAP12-associated receptor expressed on NK cells that triggers NK cell activation.

  J. Immunol.  178:647-651. [Link]

2006

• Shiroishi M, Kuroki K, Ose T, Rasubala L, Shiratori I, Arase H, Tsumoto K, Kumagai I, Kohda D, Maenaka K. 2006. Efficient leukocyte IG-like receptor signaling and crystal structure of disulfide-linked HLA-G dimer.

  J. Biol. Chem.   281:10439-10447. [Link]

2005

• Shiratori I, Yamaguchi M, Suzukawa M, Yamamoto K, Lanier LL, Saito T. Arase H 2005. Downregulation of basophil function by human CD200 and human herpesvirus-8 CD200.

  J. Immunol.  175:4441-4449. [Link]

• Arase N, Takeuchi A, Unno M, Hirano S, Yokosuka T, Arase H, Saito T. 2005. Heterotypic interaction of CRTAM with Necl2 induces cell adhesion on activated NK cells and CD8⁺ T cells.

  Int. Immunol.  17:1227-1237. [Link]

2004

• Ishikawa S, Arase N, Suenaga T, Saita Y, Noda M, Kuriyama T, Arase H, Saito T. 2004. Involvement of FcRγ in signal transduction of osteoclast-associated receptor (OSCAR).

  Int. Immunol.  16:1019-1025. [Link]

• Shiratori I, Ogasawara K, Saito T, Lanier LL, Arase H 2004. Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor.

  J. Exp. Med.  199:525-533. [Link]

• Ohtsuka M, Arase H, Takeuchi A, Yamasaki S, Shiina R, Sakurai D, Arase N, Suenaga T, Iwashima M, Kitamura T, Moriya H, Saito T. 2004. NFAM1, a new ITAM⁺ cell surface molecule that regulates development and signaling of B lymphocytes.

  Proc. Natl. Acad. Sci. USA.  101: 8126-8131 (First two authors equally contributed). [Link]

• Arase H, Lanier LL. Specific recognition of virus-infected cells by paired NK receptors.

  Rev. Med. Virol.  2004 14:83-93. [Link]

• Carlyle JR, Jamieson AM, Gasser S, Clingan CS, Arase H, Raulet DH 2004. Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors.

  Proc. Natl. Acad. Sci. USA.  101:3527-3532. [Link]

• Sakurai D, Yamasaki S, Arase K, Park SY, Arase H, Konno A, Saito T. 2004. FcεRIγ-ITAM is differentially required for mast cell function in vivo.

  J. Immunol.   172:2374-2381. [Link]

2003

• Lodoen M, Ogasawara K, Hamerman JA, Arase H, Houchins JP, Mocarski ES, Lanier LL. 2003. NKG2D-mediated natural killer cell protection against cytomegalovirus is impaired by viral gp40 modulation of retinoic acid early inducible 1 gene molecules.

  J. Exp. Med.  197:1245-1253. [Link]

• Arase N, Arase H, Hirano S, Yokosuka T, Sakurai D, and Saito T. 2003. IgE-mediated activation of NK cells through FcγRIII.

  J. Immunol.   170:3054-3058. [Link]

2002

• Arase H, Mocarski ES, Campbell AE, Hill AB, Lanier LL. 2002. Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors.

  Science  296:1323-1326. [Link]

• Arase H, Lanier LL. (2002) Virus-driven evolution of NK cell receptors.

  Microbes Infect.   4:1505-1512. [Link]

• Itoh K, Sakakibara M, Yamasaki S, Takeuchi A, Arase H, Miyazaki M, Nakajima N, Okada M, Saito T 2002. Negative regulation of immune synapse formation by anchoring lipid raft to cytoskeleton through Cbp-EBP50-ERM assembly.

  J. Immunol.  168:541-544. [Link]

• Yokosuka T, Takase K, Suzuki M, Nakagawa Y, Taki S, Takahashi H, Fujisawa T, Arase H, Saito T 2002. Predominant role of TCRα chain in forming pre-immune TCR repertoire revealed by clonal TCR reconstitution system.

  J. Exp. Med. 195:1-12. [Link]

2001

• Arase H, Saito T, Phillips JH, Lanier LL 2001. The mouse NK cell-associated antigen recognized by DX5 mAb is CD49b (α2 integrin, VLA-2).

  J. Immunol. 167: 1141-1144. [Link]

• Arase H, Suenaga T, Arase N, Kimura Y, Ito K, Shiina R, Ohno H, Saito T 2001. Negative regulation of expression and function of FcγRIII by CD3ζ in murine NK cells.

  J. Immunol. 166:21-25. [Link]

• Tomita K, Saijo K, Yamasaki S, Iida T, Nakatsu F, Arase H, Ohno H, Shirasawa T, Kuriyama T, O'Shea JJ, Saito T. 2001. Cytokine-independent Jak3 activation upon TCR stimulation through direct association of Jak3 and the TCR complex.

  J. Biol. Chem.  276: 25378-25385. [Link]

• Takeuchi A, Yamasaki S, Takase K, Nakatsu F, Arase H, Onodera M, Saito T 2001. E2A and HEB activate the pre-TCRα promoter during immature T cell development.

  J. Immunol.   167:2157-2163 [Link].

2000

• Hamano Y, Arase H, Saisho H, Saito T 2000. Immune complex and Fc receptor-mediated augmentation of antigen presentation for in vivo helper T cell responses.

  J. Immunol. 164:6113-6119. [Link]

• Nakatsu F, Sakuma M, Matsuo Y, Arase H, Yamasaki S, Nakamura N, Saito T, Ohno H. 2000. A di-leucine signal in the ubiquitin moiety: possible involvement in ubiquitination-mediated endocytosis.

  J. Biol. Chem. 275:26213-26219. [Link]

• Iida T, Ohno H, Nakaseko C, Sakuma M, Takeda-Ezaki M, Arase H, Kominami E, Fujisawa T, Saito T. 2000. Regulation of cell surface expression of CTLA-4 by secretion of CTLA-4-containing lysosomes upon activation of CD4⁺ T cells.

  J. Immunol.   165:5062-5068. [Link]

• Watanabe N, Arase H, Onodera M, Ohashi P, Saito T. 2000. The quantity of TCR signaling determines positive selection and commitment of T cells.

  J. Immunol.  165:6252-6261. [Link]

• Arase K, Saijo K, Watanabe H, Konno A, Arase H, Saito T. (1999) Ablation of a specific cell population by the replacement of an uniquely expressed gene with a toxin gene.Proc. Natl. Acad. Sci. USA96: 9264-9268.

1998

• Park SY, Ueda S, Ohno H, Hamano Y, Tanaka M, Shiratori T, Yamazaki T, Arase H, Arase N, Karasawa A, Sato S, Ledermann B, Kondo Y, Okumura K, Ra C, Saito T. (1998) Resistance of Fc receptor- deficient mice to fatal glomerulonephritis.J. Clin. Invest.102: 1229-1238.

1997

• Arase N, Arase H, Park SY, Ohno H, Ra C, Saito T. （1997） Association with FcRg is essential for activation signal through NKR-P1 (CD161) NK cells and NK1.1⁺ T cells.J. Exp. Med. 186:1957-1963. (First two authors equally contributed)

• Saijo K, Park SY, Ishida Y, Arase H, Saito T.（1997）Crucial role of Jak3 in negative selection of self-reactive T cells.J. Exp. Med. 185:351-356.

• Yamazaki T, Arase H, Ono S, Ohno H, Watanabe H, Saito T.（1997） A shift from negative to positive selection of autoreactive T cells by the reduced level of TCR signal in TCR-transgenic CD3ζ-deficient mice.J. Immunol.158:1634-1640.

• Onoe K, Arase N, Arase H, Takayanagi T, Nishihori H, Iwabuchi K, Ogasawara K, Good RA. （1997） Influence of graft versus host reaction on the T cell repertoire differentiating from bone marrow precursors following allogeneic bone marrow transplantation.Transpl. Immunol.5:75-82.

• Watanabe N, Arase H, Kurasawa K, Iwamoto I, Kayagaki N, Yagita H, Okumura K, Miyatake S Saito T.（1997） Th1 and Th2 subsets equally undergo Fas-dependent and independent activation-induced cell death.Eur. J. Immunol.27:1858-1864.

1996

• Arase H, Arase N, Saito T （1996） Interferon-γ production by natural killer cells and NK1.1⁺ T cells upon NKR-P1 cross-linking.J. Exp. Med. 183:2391-2396.

• Arase N, Arase H, Ohki K, Nishino Y, Ikuta K, Onoe K.（1996）Mitogenic effect of HIV-infected human T cell lines on mouse B cells mediated by surface immunoglobulin.Clin. Exp. Immunol. 103:24-29

• Aoe T, Okamoto Y, Arase H, Ikuta K, Miyazaki J, Ono S, Ohono H, Miyatake S, Saito T （1996） Preferential requirement of CD3-z-mediated signals for development of immature rather than mature thymocytes.Int. Immunol.8:1055-1066.

1995

• Arase H, Arase N, Saito T　（1995） Fas-mediated cytotoxicity by freshly isolated natural killer cells.J. Exp. Med.181: 1235-1238.

• Arase H, Ono S, Arase N, Park SY, Wakizaka K, Watanabe H, Ohno H, Saito T （1995） Developmental arrest of NK1.1⁺ T cell receptor (TCR)-αβ⁺ T cells and expansion of NK1.1⁺ TCR-γ/δ⁺ T cell development in CD3z-deficient mice.J. Exp. Med.182:891-895.

• Park SY, Arase H, Wakizaka K, Hirayama N, Masaki S, Sato S, Ravetch JV, Saito T （1995）Differential contribution of the FcR-γ chain to the surface expression of the T cel receptor among T cells localized in epithelia: analysis of FcR-g-deficient mice.Eur. J. Immunol.25:2107-2110.

• Arase N, Arase H, Takayanagi T, Mishima M, Iwabuchi K, Ogasawara K, Onoe K. （1995） Production of minor lymphocyte stimulatory-1a antigens from T cell subsets.Immunobiology 193:378-390.

• Park SY, Saijo K, Takahashi T, Osawa M, Arase H, Hirayama N, Miyake K, Nakauchi H, Shirasawa T, Saito T.（1995）Developmental defects of lymphoid cells in Jak3 kinase-deficient mice.Immunity3:771-782.

1994

• Arase H, Arase N, Kobayashi Y, Nishimura Y, Yonehara S, and Onoe K.（1994） Cytotoxicity of fresh NK1.1⁺ T-cell receptor ab⁺thymocytes against a CD4⁺8⁺ thymocyte population associated with intact Fas antigen expression on the target.J. Exp. Med.180: 423-432.

• Ohgama J, Katoh M, Hirano M, Arase H, Arase-Fukushi N, Mishima M, Iwabuchi K, Ogasawara K, Onoe K.（1994）Functional studies on MEL-14⁺ and MEL-14^- T cells in peripheral lymphoid tissues.Immunobiology190: 225-242.

• Wambua PP, Iwabuchi K, Iwabuchi C, Ogasawara K, Itoh Y, Arase H, Kajiwara M, Gotohda T, Kajino K, Good RA, Onoe K. （1994） Comparative analyses of thymocyte and thymic low-density adherent cell functions.Microbiol. Immunol. 38: 879-890.

• Arase N, Arase H, Good RA, Onoe K. （1994） Contribution of host radio-resistant T cells to the clonal elimination of minor lymphocyte stimulatory-1a reactive T cells in mouse bone marrow chimeras.Cell. Immunol. 156: 13-23.

1993

• Arase H, Arase N, Nakagawa K, Good RA, Onoe K.（1993）NK1.1⁺ CD4⁺CD8^- thymocytes with specific lymphokine secretion.Eur. J. Immunol.23: 307-310.

• Arase H, Arase-Fukushi N, Good RA, Onoe K. （1993） Lymphokine activated killer cell activity of CD4^-CD8^- TCRαβ⁺thymocytes.J. Immunol.151: 546-555.

• Hirano M, Arase H, Arase-Fukushi N, Ogasawara K, Good RA, Onoe K.（1993） Reconstitution of lymphoid tissues under the influence of subclinical level of graft versus host reaction induced by bone marrow cells or splenic T cell subsets.Cell. Immunol. 151: 118-132.

• Arase-Fukushi N, Arase H, Ogasawara K, Good RA, Onoe K.（1993） Production of Mls-1a antigen from activated CD4⁺ or CD8⁺ T cells.J. Immunol. 151: 4445-4454.

• Arase-Fukushi N, Arase H, Ogasawara K, Good RA, Onoe K.（1993） Production of Mls-1a antigen from activated CD4⁺ or CD8⁺ T cells.J. Immunol. 151: 4445-4454.

• Arase-Fukushi N, Arase H, Wang B, Hirano M, Ogasawara K, Good RA, Onoe K. （1993）Influence of a small number of mature T cells in donor bone marrow inocula on reconstitution of lymphoid tissues and negative selection of a T cell repertoire in the recipient.Microbiol. Immunol.37: 883-894.

1992

• Arase H, Arase N, Ogasawara K, Good RA, Onoe K.（1992）Clonal elimination of self reactive Vβ6⁺ T cells induced by H-2 products expressed on thymic radio-resistant components. Int. Immunol.4: 75-82.

• Arase H, Arase N, Ogasawara K, Good RA, Onoe K. （1992） An NK1.1⁺ CD4⁺8^- single positive thymocyte subpopulation that expresses a highly skewed T-cell antigen receptor Vb family.Proc. Natl. Acad. Sci. USA89: 6506-6510.

1991

• Iwabuchi C, Iwabuchi K, Kobayashi S, Ogasawara K, Negishi I, Wang B, Wambua PP, Arase H, Fukushi N, Itoh Y, Gotohda T, Good RA, Onoe K. （1991） Deficiency in early development of the thymus-dependent cells in irradiation chimeras attributable to recipient's environment.J. Immunol. 146: 26-34.

1990

• Arase H, Fukushi N, Hatakeyama S, Ogasawara K, Iwabuchi K, Iwabuchi C, Negishi I, Good RA, Onoe K.（1990）Sequential analysis of the thymocyte differentiation in fully allogeneic bone marrow chimera in mice. II. Further characterization of the CD4⁺ or CD8⁺single-positive thymocytes.Immunobiology180: 167-183.

• Ogasawara K, Fukushi N, Arase H, Iwabuchi C, Hatakeyama S, Iwabuchi K, Good RA, Onoe K.（1990）Sequential analysis of the thymocyte differentiation in fully allogeneic bone marrow chimera in mice. I. Relationship between functions and surface characteristics of thymocytes.Immunobiology180: 149-166.

• Fukushi N, Wang B, Arase H, Ogasawara K, Good RA, Onoe K.（1990） Cell components required for deletion of an autoreactive T cell repertoire.Eur. J. Immunol.20: 1153-1160.

• Fukushi N, Arase H, Wang B, Ogasawara K, Gotohda T, Good RA, Onoe K. （1990）Thymus: A direct target tissue in graft-versus-host reaction after allogeneic bone marrow transplantation that results in abrogation of induction of self-tolerance.Proc. Natl. Acad. Sci. USA87: 6301-6305.

1989

• Onoe K, Iwabuchi K, Katsume C, Arase H, Hatakeyama S, Wambua PP, Fukushi N, Negishi I, Good RA, Ogasawara K.（1989）Donor and recipient specific tolerance in cells from semi-allogeneic, H-2 subregion compatible or fully allogeneic bone marrow chimeras attributable to clonal deletion.Immunobiology179: 172-189.

• Iwabuchi K, Negishi I, Arase H, Iwabuchi C, Ogasawara K, Good RA, Onoe K.（1989） Positive selection of a T-cell subpopulation in the thymus in which it develops.Proc. Natl. Acad. Sci. USA86: 5089-5093.

• Onoe K, Iwabuchi K, Katsume C, Gotohda T, Arase H, Hatakeyama S, Mishima M, Good RA, Ogasawara K.（1989）A study on graft-versus-host reaction (GVHR) by simonsen's splenomegaly assay.Acta. Pathol. Jpn. 39: 101-110.